QUADAS-2 appraises risk of bias and applicability in diagnostic accuracy studies. Assessment runs across four domains with signalling questions, separately rating risk of bias and applicability to the review question.
Diagnostic accuracy studies that compare an index test with a reference standard.
Each domain is rated for risk of bias (low / high / unclear) via signalling questions; the first three are also rated for applicability. Low risk requires that no signalling question flags a problem.
Applied in systematic reviews of diagnostic test accuracy.
The platform applies QUADAS-2 to full-text project articles and shows a supporting excerpt beneath each judgement.
