RoB 2 (Cochrane Risk of Bias 2) is a tool for appraising risk of bias in randomised controlled trials. Assessment runs across five domains with signalling questions; each domain receives a judgement (low risk / some concerns / high risk), then an overall judgement is derived.
Randomised controlled trials (RCTs), at the level of a specific outcome.
Each domain is rated from its signalling questions as low risk, some concerns, or high risk. The overall risk for the outcome is driven by the worst domain: high if any domain is high risk or multiple raise concerns.
Applied to randomised controlled trials within a systematic review to assess the reliability of the intervention effect.
The platform applies RoB 2 to full-text project articles and shows a supporting excerpt beneath each judgement.
